Title : An evaluation of cytochrome P450 isoform activities in the female dark agouti (DA) rat: relevance to its use as a model of the CYP2D6 poor metaboliser phenotype.

Pub. Date : 1994 Apr 20

PMID : 8185638






1 Functional Relationships(s)
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1 By using quinine as a specific inhibitor of the enzyme, CYP2D1 was identified as an intermediate affinity site in the Wistar strain and was shown to have impaired activity in the DA strain. Quinine cytochrome P450, family 2, subfamily d, polypeptide 1 Rattus norvegicus