Title : Cyclic hexapeptide endothelin receptor antagonists highly potent for both receptor subtypes ETA and ETB.

Pub. Date : 1994 May 16

PMID : 8185629






2 Functional Relationships(s)
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Protein Name
Organism
1 Further modification led to the discovery of cyclo(-D-Asp-Asp(Php)-Asp-D-Thg-Leu-D-Trp-) (Asp(Php): 1-beta-aspartyl-4-phenylpiperazine; Thg: 2-(2-thienyl)glycine) that inhibited [125I]ET-1 binding to the ETA and ETB receptors with IC50 values of 0.082 nM and 120 nM, respectively. AMINO-THIOPHEN-2-YL-ACETIC ACID N-acylsphingosine amidohydrolase 1 Homo sapiens
2 Further modification led to the discovery of cyclo(-D-Asp-Asp(Php)-Asp-D-Thg-Leu-D-Trp-) (Asp(Php): 1-beta-aspartyl-4-phenylpiperazine; Thg: 2-(2-thienyl)glycine) that inhibited [125I]ET-1 binding to the ETA and ETB receptors with IC50 values of 0.082 nM and 120 nM, respectively. AMINO-THIOPHEN-2-YL-ACETIC ACID N-acylsphingosine amidohydrolase 1 Homo sapiens