Title : The complex interplay of the DQB1 and DQA1 loci in the generation of the susceptible and protective phenotype for insulin-dependent diabetes mellitus.

Pub. Date : 1994 Apr

PMID : 8183282






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 IDDM status strongly correlated with DQB1 alleles carrying a non-aspartic acid residue in position 57 of DQ beta chain and DQA1 alleles with an arginine residue in position 52 of DQ alpha chain. Aspartic Acid major histocompatibility complex, class II, DQ beta 1 Homo sapiens
2 On the other hand the presence of two DQB1 alleles with aspartic acid in position 57 was sufficient to confer resistance to disease irrespective of the DQA1 genotype. Aspartic Acid major histocompatibility complex, class II, DQ beta 1 Homo sapiens