Title : Positive and negative regulation of the erythropoietin gene.

Pub. Date : 1994 Mar 25

PMID : 8132641






5 Functional Relationships(s)
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1 In order to investigate positive and negative regulatory elements of the erythropoietin (Epo) gene, synthetic oligonucleotides were designed to control Epo transcription by means of an antigen strategy. Oligonucleotides erythropoietin Homo sapiens
2 In order to investigate positive and negative regulatory elements of the erythropoietin (Epo) gene, synthetic oligonucleotides were designed to control Epo transcription by means of an antigen strategy. Oligonucleotides erythropoietin Homo sapiens
3 In order to investigate positive and negative regulatory elements of the erythropoietin (Epo) gene, synthetic oligonucleotides were designed to control Epo transcription by means of an antigen strategy. Oligonucleotides erythropoietin Homo sapiens
4 The addition of antisense oligonucleotide for CACCC elements decreased the production of Epo mRNA in a dose-dependent fashion when cells were stimulated by CoCl2 or hypoxia. Oligonucleotides erythropoietin Homo sapiens
5 In contrast, the addition of antisense oligonucleotide for the GATA element caused a dose-dependent stimulation of Epo mRNA production either in the presence or absence of CoCl2 or hypoxia. Oligonucleotides erythropoietin Homo sapiens