Title : Synthesis and neurokinin antagonist activity of 2-benzylidene- and 2-benzyl-3-benzylamino quinuclidines.

Pub. Date : 1993 Oct

PMID : 8117379






1 Functional Relationships(s)
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1 Molecular modeling studies based on the potent NK-1 antagonist CP-96,345 led us to the identification of some 2-benzylidene- and 2-benzyl-3-benzylaminoquinuclidine derivatives as potential antagonists at the NK receptor subtypes. CP96 killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 Homo sapiens