Title : Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor.

Pub. Date : 1994 Feb 18

PMID : 8106527






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In response to brain-derived neurotrophic factor and neurotrophin-3 treatment, TrkB expressed exogenously in Rat-2 cells is rapidly phosphorylated on tyrosine residues. Tyrosine neurotrophic receptor tyrosine kinase 2 Rattus norvegicus
2 At least 2 regions of TrkB contain phosphorylated tyrosines. Tyrosine neurotrophic receptor tyrosine kinase 2 Rattus norvegicus
3 Following activation of TrkB, phospholipase C-gamma 1 is phosphorylated on Tyr-783, Tyr-771, and Tyr-1254. Tyrosine neurotrophic receptor tyrosine kinase 2 Rattus norvegicus
4 Following activation of TrkB, phospholipase C-gamma 1 is phosphorylated on Tyr-783, Tyr-771, and Tyr-1254. Tyrosine neurotrophic receptor tyrosine kinase 2 Rattus norvegicus
5 Following activation of TrkB, phospholipase C-gamma 1 is phosphorylated on Tyr-783, Tyr-771, and Tyr-1254. Tyrosine neurotrophic receptor tyrosine kinase 2 Rattus norvegicus
6 Since phosphorylation of Tyr-783 and Tyr-1254 results in activation of phospholipase C-gamma 1, we predict that neurotrophin-3 leads to activation of phospholipase C-gamma 1 following binding to TrkB in Rat-2 cells. Tyrosine neurotrophic receptor tyrosine kinase 2 Rattus norvegicus