Title : Gas-uptake pharmacokinetics and biotransformation of 1,1-dichloro-1-fluoroethane (HCFC-141b).

Pub. Date : 1993 Jul-Aug

PMID : 8104122






2 Functional Relationships(s)
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1 Diallyl sulfide, a selective, mechanism-based inhibitor of cytochrome P-450 2E1, inhibited the metabolism of HCFC-141b, as indicated by a decreased uptake of HCFC-141b and by a lowered urinary excretion of 2,2-dichloro-2-fluoroethanol in diallyl-sulfide-treated rats. allyl sulfide cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus
2 Diallyl sulfide, a selective, mechanism-based inhibitor of cytochrome P-450 2E1, inhibited the metabolism of HCFC-141b, as indicated by a decreased uptake of HCFC-141b and by a lowered urinary excretion of 2,2-dichloro-2-fluoroethanol in diallyl-sulfide-treated rats. allyl sulfide cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus