Pub. Date : 1994 Sep
PMID : 8092257
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Administration of dexamethasone for 1 and 2 days (600 micrograms/kg twice daily and 2 h before animals were killed) increased NHE-3 mRNA abundance 1.3- and 2.5-fold, respectively, but had no effect on NHE-1 mRNA abundance. | Dexamethasone | solute carrier family 9 member A3 | Homo sapiens |
| 2 | Incubation of proximal tubules for 3 h with 10(-5) M dexamethasone increased proximal tubule Na+/H+ antiporter activity from 0.69 +/- 0.04 to 0.92 +/- 0.03 pH units/min (P < 0.01); however, there was no increase in NHE-3 or NHE-1 mRNA abundance. | Dexamethasone | solute carrier family 9 member A3 | Homo sapiens |
| 3 | Thus chronic dexamethasone increases NHE-3 but not NHE-1 mRNA abundance. | Dexamethasone | solute carrier family 9 member A3 | Homo sapiens |