Pub. Date : 1994 Sep
PMID : 8080048
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By administering physiological doses of interleukin-1 (IL-1) concurrently with multiple low doses of the beta cell toxin streptozotocin (MSZ), we observed an augmentation of diabetes by IL-1 in four different strains of mice. | CHEMBL4458573 | interleukin 1 complex | Mus musculus |
| 2 | Augmentation of hyperglycemia by IL-1 was most prominent in the two MSZ-resistant mouse strains Balb/cJ and A/J. | CHEMBL4458573 | interleukin 1 complex | Mus musculus |
| 3 | Furthermore, concurrent treatment with IL-1 and MSZ rendered these MSZ-resistant mice susceptible to the development of significant insulitis when compared to mice treated with MSZ alone. | CHEMBL4458573 | interleukin 1 complex | Mus musculus |
| 4 | Furthermore, concurrent treatment with IL-1 and MSZ rendered these MSZ-resistant mice susceptible to the development of significant insulitis when compared to mice treated with MSZ alone. | CHEMBL4458573 | interleukin 1 complex | Mus musculus |
| 5 | We conclude that IL-1 synergizes with MSZ to augment diabetes in mice that are normally resistant to the diabetogenic effects of MSZ. | CHEMBL4458573 | interleukin 1 complex | Mus musculus |