Title : Neuroendocrine and reproductive consequences of overexpression of growth hormone in transgenic mice.

Pub. Date : 1994 Sep

PMID : 8073044






1 Functional Relationships(s)
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1 Overexpression of human GH which, in the mouse, interacts with both GH and PRL receptors leads to additional endocrine and reproductive abnormalities including stimulation of LH beta mRNA levels and LH secretion, loss of responsiveness to testosterone feedback, overstimulation of mammary glands, enhanced mammary tumorigenesis, and hypertrophy of accessory reproductive glands in males. Testosterone growth hormone Mus musculus