Title : 1-Methyl-4-phenylpyridinium-like neurotoxicity of a pyridinium metabolite derived from haloperidol: cell culture and neurotransmitter uptake studies.

Pub. Date : 1994 Aug

PMID : 8071874






1 Functional Relationships(s)
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1 It is now generally accepted that the nigrostriatal degenerative properties of the parkinsonian-inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine are mediated by the brain monoamine oxidase B generated 1-methyl-4-phenylpyridinium metabolite (MPP+). 1-Methyl-4-phenylpyridinium monoamine oxidase B Homo sapiens