Title : Reversal of clavulanate resistance conferred by a Ser-244 mutant of TEM-1 beta-lactamase as a result of a second mutation (Arg to Ser at position 164) that enhances activity against ceftazidime.

Pub. Date : 1994 May

PMID : 8067751






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The doubly mutated derivative of the TEM-1 enzyme (Ser-164/Ser-244) retains the characteristics of the Ser-164 mutant enzyme, i.e., enhanced activity against ceftazidime and sensitivity to inactivation by clavulanate. Serine hypothetical protein Escherichia coli