Title : Design and synthesis of seco-oxysterol analogs as potential inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase gene transcription.

Pub. Date : 1994 Jul 22

PMID : 8057282






1 Functional Relationships(s)
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1 In the same system, the related oxysterol, 25-hydroxycholesterol (1), at 10 microM lowered both HMGR mRNA levels and LDL-receptor activity by 58% and 64%, respectively. 25-hydroxycholesterol low density lipoprotein receptor Homo sapiens