Title : Synergistic release from glucose repression by mig1 and ssn mutations in Saccharomyces cerevisiae.

Pub. Date : 1994 May

PMID : 8056322






4 Functional Relationships(s)
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1 In the yeast Saccharomyces cerevisiae, glucose repression of SUC2 transcription requires the SSN6-TUP1 repressor complex. Glucose beta-fructofuranosidase SUC2 Saccharomyces cerevisiae S288C
2 Here we show that a mig1 deletion does not cause nearly as dramatic a loss of repression as ssn6: glucose-grown mig1 mutants display 20-fold lower SUC2 expression than ssn6 mutants. Glucose beta-fructofuranosidase SUC2 Saccharomyces cerevisiae S288C
3 We show that mig1 acts synergistically with ssn2 through ssn5, ssn7, and ssn8 to relieve glucose repression of SUC2 and to suppress the requirement for SNF1. Glucose beta-fructofuranosidase SUC2 Saccharomyces cerevisiae S288C
4 Finally, the regulated SUC2 expression observed in snf1 mig1 mutants indicates that signals regarding glucose availability can be transmitted independently of the SNF1 protein kinase. Glucose beta-fructofuranosidase SUC2 Saccharomyces cerevisiae S288C