Title : Effects of a 2,3-oxidosqualene-lanosterol cyclase inhibitor 2,3:22,23-dioxidosqualene and 24,25-epoxycholesterol on the regulation of cholesterol biosynthesis in human hepatoma cell line HepG2.

Pub. Date : 1994 Jul 5

PMID : 8043030






2 Functional Relationships(s)
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1 The accumulation of 24,25-epoxycholesterol in relationship to the decrease of C27-sterol biosynthesis and of HMG-CoA reductase activity showed only a partial correlation: e.g. at [1] = 100 x IC50 only a 50% reduction in enzyme activity could be attained. 24,25-epoxycholesterol 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens
2 In contrast, when HepG2 cells were treated with 2,3:22,23-dioxidosqualene or 24,25-epoxycholesterol, excellent correlations were found between the inhibition of C27-sterol biosynthesis and the repression of HMG-CoA reductase activity, which was almost complete at the highest concentrations of these epoxides (10(-5) M). 24,25-epoxycholesterol 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens