Title : Cytochrome P450 destruction and radical scavenging by benzene and its metabolites. Evidence for the key role of quinones.

Pub. Date : 1994 Jun 15

PMID : 8031317






3 Functional Relationships(s)
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1 In this paper we followed the ability of benzene and its metabolites, phenol, catechol, hydroquinone and benzoquinone to destroy CYP in liver microsomes from PB rats in vitro. catechol cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
2 (2) Quinonic metabolites of benzene cause CYP destruction with different potency (30% CYP was destroyed by 3 mM catechol, 0.3 mM hydroquinone and 0.03 mM benzoquinone). catechol cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
3 (2) Quinonic metabolites of benzene cause CYP destruction with different potency (30% CYP was destroyed by 3 mM catechol, 0.3 mM hydroquinone and 0.03 mM benzoquinone). catechol cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus