Title : Pharmacological profiles of a novel aldose reductase inhibitor, SPR-210, and its effects on streptozotocin-induced diabetic rats.

Pub. Date : 1994 Feb

PMID : 8028228






2 Functional Relationships(s)
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1 Sorbitol accumulation in isolated human erythrocytes was effectively inhibited by SPR-210 during incubation with 50 mM glucose (IC50 = 1.6 x 10(-8) M). Sorbitol TGFB1-induced anti-apoptotic factor 1 Homo sapiens
2 Moreover, the deterioration in motor nerve conduction velocity in diabetic rats was ameliorated by treatment with SPR-210 (1-30 mg/kg/day) accompanying the reduction in sorbitol content in the sciatic nerve. Sorbitol TGFB1-induced anti-apoptotic factor 1 Homo sapiens