Title : Ontogeny of erythropoietin gene expression in the sheep fetus: effect of dexamethasone at 60 days of gestation.

Pub. Date : 1994 Jul 15

PMID : 8025273






4 Functional Relationships(s)
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1 The effect of dexamethasone infusion in the ewe on Epo gene expression in the 60-day fetus was also investigated. Dexamethasone erythropoietin Ovis aries
2 Treatment of ewes carrying 60-day fetuses with 0.76 mg/h dexamethasone for 48 hours resulted in a significant decrease in fetal plasma Epo values and Epo mRNA levels in both the liver and kidney. Dexamethasone erythropoietin Ovis aries
3 Treatment of ewes carrying 60-day fetuses with 0.76 mg/h dexamethasone for 48 hours resulted in a significant decrease in fetal plasma Epo values and Epo mRNA levels in both the liver and kidney. Dexamethasone erythropoietin Ovis aries
4 In the dexamethasone-treated fetuses, Epo mRNA in the liver was 52% of control values (P < .05), and in the kidney, 33% of control (P < .001). Dexamethasone erythropoietin Ovis aries