Title : Identification of intracellular domains in the growth hormone receptor involved in signal transduction.

Pub. Date : 1994 Jul

PMID : 8016155






1 Functional Relationships(s)
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1 These results indicate that the intracellular part of the GH receptor can be divided into at least three functional domains: (i) for transcriptional activity, two domains are involved, one located in the C-terminal 184 amino acids and the other in the proline-rich domain; (ii) for metabolic effects, a domain located in or near the proline-rich region is of importance; and (iii) for internalization, phenylalanine 346 is necessary. Phenylalanine growth hormone receptor Homo sapiens