Title : Suppressors reveal two classes of glucose repression genes in the yeast Saccharomyces cerevisiae.

Pub. Date : 1994 Apr

PMID : 8013904






5 Functional Relationships(s)
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1 We selected and analyzed extragenic suppressors of mutations in four genes--GRR1, REG1, GAL82 and GAL83-required for glucose repression of the GAL genes in the yeast Saccharomyces cerevisiae. Glucose SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C
2 Tests of the ability of each suppressor to cross-suppress mutations in the other glucose repression genes revealed two groups of mutually cross-suppressed genes: (1) REG1, GAL82 and GAL83 and (2) GRR1. Glucose SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C
3 These results, together with what was previously known about these genes, lead us to propose a model for glucose repression in which Grr1p acts early in the glucose repression pathway, perhaps affecting the generation of the signal for glucose repression. Glucose SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C
4 These results, together with what was previously known about these genes, lead us to propose a model for glucose repression in which Grr1p acts early in the glucose repression pathway, perhaps affecting the generation of the signal for glucose repression. Glucose SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C
5 These results, together with what was previously known about these genes, lead us to propose a model for glucose repression in which Grr1p acts early in the glucose repression pathway, perhaps affecting the generation of the signal for glucose repression. Glucose SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C