Title : Vinca alkaloids enhance the half-life of tumour ornithine decarboxylase.

Pub. Date : 1994 Jun 30

PMID : 8012939






3 Functional Relationships(s)
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1 Naturally occurring vinca alkaloids, vincristine and vinblastine, at micromolar concentrations enhanced the ornithine decarboxylase activity in a dose-response manner in primary cultures of Ehrlich ascites carcinoma cells. Vinblastine ornithine decarboxylase, structural 1 Mus musculus
2 After 8 h of culture in the presence or absence of vinblastine, cycloheximide was added to the medium, a 4.5-fold increase in the half-life of the ornithine decarboxylase activity was observed in vinblastine-treated cells. Vinblastine ornithine decarboxylase, structural 1 Mus musculus
3 After 8 h of culture in the presence or absence of vinblastine, cycloheximide was added to the medium, a 4.5-fold increase in the half-life of the ornithine decarboxylase activity was observed in vinblastine-treated cells. Vinblastine ornithine decarboxylase, structural 1 Mus musculus