Pub. Date : 1994 Jun 14
PMID : 8003467
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Determination by Raman spectroscopy of the pKa of N5 of dihydrofolate bound to dihydrofolate reductase: mechanistic implications. | dihydrofolate | Dihydrofolate reductase | Escherichia coli |
| 2 | Dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate (H2folate) to tetrahydrofolate by NADPH, and this requires that the pteridine ring be protonated at N5. | dihydrofolate | Dihydrofolate reductase | Escherichia coli |
| 3 | Dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate (H2folate) to tetrahydrofolate by NADPH, and this requires that the pteridine ring be protonated at N5. | dihydrofolate | Dihydrofolate reductase | Escherichia coli |
| 4 | We have determined the pKa of N5 of dihydrofolate in the Escherichia coli DHFR/NADP+/H2folate ternary complex by Raman difference spectroscopy and found that the value is 6.5. | dihydrofolate | Dihydrofolate reductase | Escherichia coli |