Title : Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells.

Pub. Date : 1994 Dec 9

PMID : 7983060






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Phosphorylated IRS-1 binds to SH2 domains in the p85 regulatory subunit of phosphatidyl inositol (PI) 3-kinase, thereby stimulating the catalytic activity of PI 3-kinase. Phosphatidylinositols insulin receptor substrate 1 Homo sapiens