Pub. Date : 1994 Oct 15
PMID : 7980404
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Transforming growth factor-alpha increases tyrosine phosphorylation of microtubule-associated protein kinase in a small intestinal crypt cell line (IEC-6). | Tyrosine | transforming growth factor alpha | Rattus norvegicus |
| 2 | The small intestinal crypt cell line (IEC-6) is an undifferentiated, untransformed, mitotically active cell used in this study to determine the effect of transforming growth factor-alpha (TGF-alpha) on tyrosine phosphorylation levels of cellular proteins. | Tyrosine | transforming growth factor alpha | Rattus norvegicus |
| 3 | Thymidine incorporation increased maximally after addition of 2 ng/ml TGF-alpha for 24 h. At the same dose, TGF-alpha induced the tyrosine phosphorylation of proteins with approximate molecular masses of 42, 44, 52, 80, 150 and 175 kDa as shown by Western blots treated with anti-phosphotyrosine antibody. | Tyrosine | transforming growth factor alpha | Rattus norvegicus |
| 4 | Thymidine incorporation increased maximally after addition of 2 ng/ml TGF-alpha for 24 h. At the same dose, TGF-alpha induced the tyrosine phosphorylation of proteins with approximate molecular masses of 42, 44, 52, 80, 150 and 175 kDa as shown by Western blots treated with anti-phosphotyrosine antibody. | Tyrosine | transforming growth factor alpha | Rattus norvegicus |
| 5 | We conclude that MAPK is tyrosine phosphorylated in response to TGF-alpha stimulation of IEC-6 cells. | Tyrosine | transforming growth factor alpha | Rattus norvegicus |