Title : Muscarinic receptors transform NIH 3T3 cells through a Ras-dependent signalling pathway inhibited by the Ras-GTPase-activating protein SH3 domain.

Pub. Date : 1994 Dec

PMID : 7969134






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Point mutations at conserved residues in the Ras-GAP SH3 domain reversed its action, leading to an increase in carbachol-dependent transformation. Carbachol RAS p21 protein activator 1 Mus musculus
2 The inhibitory effect of expression of the Ras-GAP SH3 domain occurs proximal to Ras activation and is selective for the mitogenic pathway activated by carbachol, as cellular transformation by either v-Ras or trkA/nerve growth factor is unaffected. Carbachol RAS p21 protein activator 1 Mus musculus