Pub. Date : 1994 Aug
PMID : 7967352
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mesangial cells treated with 10 to 100 microM H2O2 for 24 hours showed a two- to ninefold increase in Mn-SOD mRNA expression associated with significantly (P < 0.005) increased Mn-SOD activity (22.2 +/- 1.2 and 12.2 +/- 0.7 mu/mg protein for H2O2 100 microM treated and untreated cells, respectively). | Hydrogen Peroxide | superoxide dismutase 2 | Rattus norvegicus |
| 2 | Mesangial cells treated with 10 to 100 microM H2O2 for 24 hours showed a two- to ninefold increase in Mn-SOD mRNA expression associated with significantly (P < 0.005) increased Mn-SOD activity (22.2 +/- 1.2 and 12.2 +/- 0.7 mu/mg protein for H2O2 100 microM treated and untreated cells, respectively). | Hydrogen Peroxide | superoxide dismutase 2 | Rattus norvegicus |
| 3 | Mesangial cells treated with 10 to 100 microM H2O2 for 24 hours showed a two- to ninefold increase in Mn-SOD mRNA expression associated with significantly (P < 0.005) increased Mn-SOD activity (22.2 +/- 1.2 and 12.2 +/- 0.7 mu/mg protein for H2O2 100 microM treated and untreated cells, respectively). | Hydrogen Peroxide | superoxide dismutase 2 | Rattus norvegicus |
| 4 | Induction of Mn-SOD mRNA by H2O2 was inhibited by actinomycin-D (4 microM) treatment. | Hydrogen Peroxide | superoxide dismutase 2 | Rattus norvegicus |
| 5 | Mesangial and epithelial cells transfected with pGL2P (-806:+408) and treated with H2O2 (100 microM and 1 mM for mesangial and epithelial cells, respectively) demonstrated some threefold increase in luciferase activity, whereas cells transfected with pGL2P lacking the Mn-SOD fragment did not show changes in luciferase activity following H2O2 treatment. | Hydrogen Peroxide | superoxide dismutase 2 | Rattus norvegicus |