Title : Sugar chain heterogeneity of human urinary chorionic gonadotropin determined by serial lectin affinity chromatography: difference between benign and malignant disease.

Pub. Date : 1994

PMID : 7939172






3 Functional Relationships(s)
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1 Human chorionic gonadotropin (hCG) is a glycoprotein of which sugar chains are considered to show structural changes with malignancy. Sugars hypertrichosis 2 (generalised, congenital) Homo sapiens
2 To study the sugar chain heterogeneity of urinary hCG in patients with gynecological disease, we employed serial lectin affinity chromatography (LAC) using concanavalin A (Con A) and phytohemagglutinin-E (PHA-E) which can separate N-glycoside-linked sugar chains, and Jacalin lectin which is specific for O-glycoside-linked sugar chains. Sugars hypertrichosis 2 (generalised, congenital) Homo sapiens
3 Taken together, these results show that alteration in sugar chain structures of hCG reflect the advanced stage of cervical cancer. Sugars hypertrichosis 2 (generalised, congenital) Homo sapiens