Title : Introduction of a disulfide bond into ricin A chain decreases the cytotoxicity of the ricin holotoxin.

Pub. Date : 1994 Oct 28

PMID : 7929403






3 Functional Relationships(s)
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1 In the presence of glutathione and protein disulfide isomerase, this RTA variant reassociated with RTB to form ricin holotoxin. stichoposide MAS related GPR family member F Homo sapiens
2 Incubation of this holotoxin with increasing concentrations of dithiothreitol showed that the interchain disulfide bond joining RTA and RTB was more readily reduced than the intrachain disulfide bond in RTA. stichoposide MAS related GPR family member F Homo sapiens
3 Incubation of this holotoxin with increasing concentrations of dithiothreitol showed that the interchain disulfide bond joining RTA and RTB was more readily reduced than the intrachain disulfide bond in RTA. stichoposide MAS related GPR family member F Homo sapiens