Pub. Date : 1994 Sep 29
PMID : 7918668
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Yeast calmodulin binds only three calcium ions in the presence of millimolar concentrations of magnesium due to a defective calcium-binding sequence in its carboxyl terminal domain. | Calcium | calmodulin | Saccharomyces cerevisiae S288C |
| 2 | Yeast calmodulin binds only three calcium ions in the presence of millimolar concentrations of magnesium due to a defective calcium-binding sequence in its carboxyl terminal domain. | Calcium | calmodulin | Saccharomyces cerevisiae S288C |
| 3 | Yeast calmodulin"s diminished calcium-binding activity can be restored to that of other calmodulins by the use of site-directed mutagenesis to substitute its fourth calcium-binding domain with that of a vertebrate calmodulin sequence. | Calcium | calmodulin | Saccharomyces cerevisiae S288C |
| 4 | Yeast calmodulin"s diminished calcium-binding activity can be restored to that of other calmodulins by the use of site-directed mutagenesis to substitute its fourth calcium-binding domain with that of a vertebrate calmodulin sequence. | Calcium | calmodulin | Saccharomyces cerevisiae S288C |
| 5 | Yeast calmodulin"s diminished calcium-binding activity can be restored to that of other calmodulins by the use of site-directed mutagenesis to substitute its fourth calcium-binding domain with that of a vertebrate calmodulin sequence. | Calcium | calmodulin | Saccharomyces cerevisiae S288C |
| 6 | Yeast calmodulin"s diminished calcium-binding activity can be restored to that of other calmodulins by the use of site-directed mutagenesis to substitute its fourth calcium-binding domain with that of a vertebrate calmodulin sequence. | Calcium | calmodulin | Saccharomyces cerevisiae S288C |
| 7 | However, the repair of yeast calmodulin"s calcium-binding activity is not sufficient to repair quantitatively yeast calmodulin"s defective protein kinase activator activity. | Calcium | calmodulin | Saccharomyces cerevisiae S288C |
| 8 | Yeast calmodulin"s activator activity with smooth muscle and skeletal muscle myosin light chain kinases and brain calmodulin-dependent protein kinase II can be progressively repaired by additional substitutions of vertebrate calmodulin sequences, provided that the four calcium-binding sites remain intact. | Calcium | calmodulin | Saccharomyces cerevisiae S288C |
| 9 | These and previous results indicate that the binding of four calcium ions by calmodulin is necessary but not sufficient to bring about quantitative activation of protein kinases, and are consistent with the conformational selection/restriction model of the dynamic equilibrium among calcium, calmodulin and each calmodulin regulated enzyme. | Calcium | calmodulin | Saccharomyces cerevisiae S288C |
| 10 | These and previous results indicate that the binding of four calcium ions by calmodulin is necessary but not sufficient to bring about quantitative activation of protein kinases, and are consistent with the conformational selection/restriction model of the dynamic equilibrium among calcium, calmodulin and each calmodulin regulated enzyme. | Calcium | calmodulin | Saccharomyces cerevisiae S288C |
| 11 | These and previous results indicate that the binding of four calcium ions by calmodulin is necessary but not sufficient to bring about quantitative activation of protein kinases, and are consistent with the conformational selection/restriction model of the dynamic equilibrium among calcium, calmodulin and each calmodulin regulated enzyme. | Calcium | calmodulin | Saccharomyces cerevisiae S288C |
| 12 | These and previous results indicate that the binding of four calcium ions by calmodulin is necessary but not sufficient to bring about quantitative activation of protein kinases, and are consistent with the conformational selection/restriction model of the dynamic equilibrium among calcium, calmodulin and each calmodulin regulated enzyme. | Calcium | calmodulin | Saccharomyces cerevisiae S288C |