Title : Effect of suramin on adenylate cyclase and protein kinase C.

Pub. Date : 1994 Aug

PMID : 7916897






3 Functional Relationships(s)
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1 Six day exposure of these cell lines to suramin, causing 50% growth inhibition, decreased the Ca(2+)- and phospholipid-dependent PKC activity in MCF-7 cells to 52% of the control and in PC3 cells to 48% at equitoxic concentrations (45 and 150 microM suramin, respectively). Suramin chromobox 8 Homo sapiens
2 In MCF-7 and PC3 cells, we measured the [Ca2+]i using Fura-2 fluorescence and observed a decrease in MCF-7 cells from 126 to 99 nM when the cells were exposed for 6 days to 45 microM suramin. Suramin chromobox 8 Homo sapiens
3 In PC3 cells, [C2+]i decreased from 131 to 117 nM after exposure to 150 microM suramin. Suramin chromobox 8 Homo sapiens