Pub. Date : 1994 Jul
PMID : 7913292
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PURPOSE: The aim of the present study was to evaluate in vivo and in vitro beta 2-adrenoceptor responsiveness after chronic inhaled therapy with the long-acting beta 2-agonist eformoterol or placebo, given twice daily, in patients with mild to moderate asthma. | Formoterol Fumarate | potassium calcium-activated channel subfamily M regulatory beta subunit 2 | Homo sapiens |
| 2 | Dose-response curves (DRC) to eformoterol (cumulative dose 6 micrograms to 126 micrograms) for airways and systemic beta 2-responses were constructed at the end of each treatment period. | Formoterol Fumarate | potassium calcium-activated channel subfamily M regulatory beta subunit 2 | Homo sapiens |
| 3 | CONCLUSIONS: Our results suggest that chronic therapy with eformoterol produces (1) tachyphylaxis to its bronchodilator response, which was greatest at 6 hours after the last dose, (2) tachyphylaxis of extrapulmonary beta 2-mediated responses, and (3) subsensitivity of in vitro beta 2-adrenoceptor function. | Formoterol Fumarate | potassium calcium-activated channel subfamily M regulatory beta subunit 2 | Homo sapiens |