Pub. Date : 1994 Apr
PMID : 7910373
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We have undertaken to characterize the role of cytoplasmic 5"-nucleotidase (EC 3.1.3.5) in the phosphorylation of the anti-herpes simplex virus and anti-human cytomegalovirus agent ganciclovir (GCV) in MOLT-4 cells, a human T cell line adapted to grow in suspension culture. | Ganciclovir | 5'-nucleotidase ecto | Homo sapiens |
2 | We have undertaken to characterize the role of cytoplasmic 5"-nucleotidase (EC 3.1.3.5) in the phosphorylation of the anti-herpes simplex virus and anti-human cytomegalovirus agent ganciclovir (GCV) in MOLT-4 cells, a human T cell line adapted to grow in suspension culture. | Ganciclovir | 5'-nucleotidase ecto | Homo sapiens |
3 | Thus, agents that enhance 5"-nucleotidase-catalyzed phosphorylation of GCV in uninfected cells do not play a similar role in HStk-transfected cells, a consequence of the quantitative predominance of the viral thymidine kinase-catalyzed reaction over that attributable to endogenous cytoplasmic 5"-nucleotidase. | Ganciclovir | 5'-nucleotidase ecto | Homo sapiens |