Title : Effects of IMP dehydrogenase inhibitors on the phosphorylation of ganciclovir in MOLT-4 cells before and after herpes simplex virus thymidine kinase gene transduction.

Pub. Date : 1994 Apr

PMID : 7910373






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We have undertaken to characterize the role of cytoplasmic 5"-nucleotidase (EC 3.1.3.5) in the phosphorylation of the anti-herpes simplex virus and anti-human cytomegalovirus agent ganciclovir (GCV) in MOLT-4 cells, a human T cell line adapted to grow in suspension culture. Ganciclovir 5'-nucleotidase ecto Homo sapiens
2 We have undertaken to characterize the role of cytoplasmic 5"-nucleotidase (EC 3.1.3.5) in the phosphorylation of the anti-herpes simplex virus and anti-human cytomegalovirus agent ganciclovir (GCV) in MOLT-4 cells, a human T cell line adapted to grow in suspension culture. Ganciclovir 5'-nucleotidase ecto Homo sapiens
3 Thus, agents that enhance 5"-nucleotidase-catalyzed phosphorylation of GCV in uninfected cells do not play a similar role in HStk-transfected cells, a consequence of the quantitative predominance of the viral thymidine kinase-catalyzed reaction over that attributable to endogenous cytoplasmic 5"-nucleotidase. Ganciclovir 5'-nucleotidase ecto Homo sapiens