Title : The role of the NAD-dependent glutamate dehydrogenase in restoring growth on glucose of a Saccharomyces cerevisiae phosphoglucose isomerase mutant.

Pub. Date : 1993 Oct 1

PMID : 7901008






2 Functional Relationships(s)
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1 Suppression of the pgi1 deletion by over-expression of GDH2 was abolished in strains with a deletion of the glucose-6-phosphate dehydrogenase gene ZWF1 or gene GDH1 coding for the NADPH-dependent glutamate dehydrogenase. NADP glucose-6-phosphate isomerase Saccharomyces cerevisiae S288C
2 It is proposed that the growth defect of pgi1 deletion mutants on glucose is due to a rapid depletion of NADP which is needed as a cofactor in the oxidative reactions of the pentose phosphate pathway. NADP glucose-6-phosphate isomerase Saccharomyces cerevisiae S288C