Pub. Date : 1995 Mar
PMID : 7896012
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Captopril increases skin microvascular blood flow secondary to bradykinin, nitric oxide, and prostaglandins. | Captopril | kininogen 1 | Homo sapiens |
| 2 | This study was designed to test whether the ACEI captopril increases skin microvascular blood flow by a bradykinin-dependent mechanism. | Captopril | kininogen 1 | Homo sapiens |
| 3 | The responses to bradykinin or captopril were abolished by coinjecting a bradykinin antagonist, a specific bradykinin B2 receptor antagonist, or inhibitors of NOS or cyclooxygenase. | Captopril | kininogen 1 | Homo sapiens |
| 4 | The results indicate that captopril increases skin microvascular blood flow in rabbits and humans secondary to an increase in endogenous tissue bradykinin; this stimulates B2 receptors with subsequent release of prostaglandins and nitric oxide. | Captopril | kininogen 1 | Homo sapiens |