Title : Induction of cytochrome P450 by toluene.

Pub. Date : 1994 Dec

PMID : 7890112






2 Functional Relationships(s)
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1 Toluene exposure induces CYP1A1/2, CYP2B1/2, CYP2E1 and CYP3A1, but decreases CYP2C11/6 and CYP2A1 in adult males. Toluene cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus
2 Although structurally related chemicals of toluene also influence similar hepatic P450 isoenzymes, the degree of CYP2B1/2 induction increases, whilst that of CYP2E1 decreases with increasing molecular weight and aliphatic moieties. Toluene cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus