Title : Mutagenesis of the H-ras p21 at glycine-60 residue disrupts GTP-induced conformational change.

Pub. Date : 1995 Mar 14

PMID : 7880841






4 Functional Relationships(s)
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1 Mutagenesis of the H-ras p21 at glycine-60 residue disrupts GTP-induced conformational change. Guanosine Triphosphate HRas proto-oncogene, GTPase Homo sapiens
2 GTP induces an enhancement of fluorescence emission in complexes consisting of H-ras and the fluorescent dye 8-anilino-1-naphthalenesulfonic acid. Guanosine Triphosphate HRas proto-oncogene, GTPase Homo sapiens
3 On the basis of these observations, we propose that the GTP-induced conformational change of H-ras, a process required for H-ras activities, is impaired by the G60A mutation. Guanosine Triphosphate HRas proto-oncogene, GTPase Homo sapiens
4 On the basis of these observations, we propose that the GTP-induced conformational change of H-ras, a process required for H-ras activities, is impaired by the G60A mutation. Guanosine Triphosphate HRas proto-oncogene, GTPase Homo sapiens