Pub. Date : 1994 Dec 7
PMID : 7877606
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Isoproterenol is a beta adrenergic agonist whose effects have been attributed to the generation of cAMP. | Isoproterenol | cathelicidin antimicrobial peptide | Homo sapiens |
| 2 | Consistent with the effects of dibutyryl cAMP, we found that a low concentration of isoproterenol (10 nM) stimulated glucose transport and the translocation of GLUT4 from the low density microsomal fraction to the plasma membrane. | Isoproterenol | cathelicidin antimicrobial peptide | Homo sapiens |
| 3 | By contrast, a higher concentration of isoproterenol (1 microM) did not stimulate transport or GLUT4 translocation and furthermore inhibited dibutyryl cAMP-stimulated GLUT4 translocation. | Isoproterenol | cathelicidin antimicrobial peptide | Homo sapiens |
| 4 | This inhibitory effect was specific for cAMP since isoproterenol had no effect on insulin-stimulated GLUT4 translocation. | Isoproterenol | cathelicidin antimicrobial peptide | Homo sapiens |
| 5 | We conclude that isoproterenol has a biphasic effect on glucose transport, mediated by acute translocation of GLUT4 at low concentrations and by inhibition of intrinsic activity at high concentration, both of which may be explained by effects of cAMP. | Isoproterenol | cathelicidin antimicrobial peptide | Homo sapiens |