Title : Characterization of diethyldithiocarbamate methyl ester sulfine as an intermediate in the bioactivation of disulfiram.

Pub. Date : 1995 Feb

PMID : 7853193






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Disulfiram is bioactivated through a series of intermediates, ultimately forming S-methyl-N,N-diethylthiolcarbamate sulfoxide (DETC-Me sulfoxide), the metabolite proposed to be responsible for the in vivo inhibition of rat liver mitochondrial low Km aldehyde dehydrogenase (ALDH2). Disulfiram aldehyde dehydrogenase 2 family member Rattus norvegicus