Title : pGlutamylglutamylprolineamide modulation of growth hormone secretion in domestic fowl: antagonism of thyrotrophin-releasing hormone action?

Pub. Date : 1993 Jul

PMID : 7852885






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Pyroglutamyglutamylprolineamide (pGlu-Glu-ProNH2) is a tripeptide with structural and immunological similarities to thyrotrophin-releasing hormone (TRH; pGlu-His-ProNH2). Pyrrolidonecarboxylic Acid thyrotropin releasing hormone Gallus gallus
2 Pyroglutamyglutamylprolineamide (pGlu-Glu-ProNH2) is a tripeptide with structural and immunological similarities to thyrotrophin-releasing hormone (TRH; pGlu-His-ProNH2). Pyrrolidonecarboxylic Acid thyrotropin releasing hormone Gallus gallus
3 However, pGlu-Glu-ProNH2 suppressed TRH-induced GH release from pituitary glands incubated in vitro and competitively displaced [3H]methyl3-histidine2-TRH from pituitary membranes. Pyrrolidonecarboxylic Acid thyrotropin releasing hormone Gallus gallus
4 However, pGlu-Glu-ProNH2 suppressed TRH-induced GH release from pituitary glands incubated in vitro and competitively displaced [3H]methyl3-histidine2-TRH from pituitary membranes. Pyrrolidonecarboxylic Acid thyrotropin releasing hormone Gallus gallus
5 Submaximal GH responses of conscious and anaesthetized birds to systemic TRH challenge were, however, potentiated by prior or concomitant administration of pGlu-Glu-ProNH2. Pyrrolidonecarboxylic Acid thyrotropin releasing hormone Gallus gallus