Title : Effect of doxorubicin on glutathione and glutathione-dependent enzymes in cultured rat heart cells.

Pub. Date : 1994 Sep-Oct

PMID : 7847848






3 Functional Relationships(s)
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1 Doxorubicin significantly increased glutathione-S-transferase (GST) activity in a time-dependent fashion. Doxorubicin hematopoietic prostaglandin D synthase Rattus norvegicus
2 Doxorubicin significantly increased glutathione-S-transferase (GST) activity in a time-dependent fashion. Doxorubicin hematopoietic prostaglandin D synthase Rattus norvegicus
3 These findings demonstrate that lowered GSH or GSH reductase levels do not enhance DOX cardiotoxicity in vitro and suggest that DOX may be a substrate for GST. Doxorubicin hematopoietic prostaglandin D synthase Rattus norvegicus