Pub. Date : 1995 Jan 31
PMID : 7846072
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This work had two purposes: (i) to determine in vivo whether liver phenylalanine hydroxylase (PAH) is regulated by its substrates phenylalanine and tetrahydrobiopterin (BH4) as studies with purified enzyme suggest and (ii) to investigate in vivo the relationship between PAH activity and BH4 turnover. | Phenylalanine | phenylalanine hydroxylase | Rattus norvegicus |
| 2 | Bound BH4 appears bound to PAH; the PAH-BH4 complex has much less catalytic activity and is less readily phenylalanine activated than uncomplexed enzyme. | Phenylalanine | phenylalanine hydroxylase | Rattus norvegicus |
| 3 | The data provide support in vivo that phenylalanine and BH4 are positive and negative regulators of the activity and activation state of PAH in the proposed manner; they also imply that regulation of BH4 turnover and PAH activity are linked processes, which are both controlled by phenylalanine concentration. | Phenylalanine | phenylalanine hydroxylase | Rattus norvegicus |
| 4 | The data provide support in vivo that phenylalanine and BH4 are positive and negative regulators of the activity and activation state of PAH in the proposed manner; they also imply that regulation of BH4 turnover and PAH activity are linked processes, which are both controlled by phenylalanine concentration. | Phenylalanine | phenylalanine hydroxylase | Rattus norvegicus |
| 5 | The data provide support in vivo that phenylalanine and BH4 are positive and negative regulators of the activity and activation state of PAH in the proposed manner; they also imply that regulation of BH4 turnover and PAH activity are linked processes, which are both controlled by phenylalanine concentration. | Phenylalanine | phenylalanine hydroxylase | Rattus norvegicus |
| 6 | The data provide support in vivo that phenylalanine and BH4 are positive and negative regulators of the activity and activation state of PAH in the proposed manner; they also imply that regulation of BH4 turnover and PAH activity are linked processes, which are both controlled by phenylalanine concentration. | Phenylalanine | phenylalanine hydroxylase | Rattus norvegicus |