Title : Oxidation of R(+)- and S(-)-carvedilol by rat liver microsomes. Evidence for stereoselective oxidation and characterization of the cytochrome P450 isozymes involved.

Pub. Date : 1994 Sep-Oct

PMID : 7835220






1 Functional Relationships(s)
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Organism
1 The main enzyme concerned in the 1- and 8-hydroxylation of both enantiomers is considered to be CYP2D1 from the following observation: the marked strain differences between Sprague-Dawley and Dark Agouti rats and competitive inhibition by quinine. Quinine cytochrome P450, family 2, subfamily d, polypeptide 1 Rattus norvegicus