Title : Prostaglandins mediate the ACTH response to interleukin-1-beta instilled into the hypothalamic median eminence.

Pub. Date : 1994 Oct

PMID : 7824084






2 Functional Relationships(s)
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1 Indomethacin, an inhibitor of prostaglandin (PG) synthesis, has been shown to block both the induction of CRH secretion by IL-1 beta from hypothalamic explants, as well as the ACTH response to intravenous IL-1 beta. Indomethacin proopiomelanocortin Homo sapiens
2 The ACTH response was abolished (p < 0.005) when a low dose of indomethacin (1 mg/kg i.v.) Indomethacin proopiomelanocortin Homo sapiens