Title : Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators.

Pub. Date : 1995 Jan 10

PMID : 7819214






2 Functional Relationships(s)
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1 Analysis of the specific drug resistance profiles encoded by each P-gp for colchicine, adriamycin, vinblastine, and actinomycin D revealed overlapping but distinct patterns of drug resistance for the three isoforms. Vinblastine phosphoglycolate phosphatase Homo sapiens
2 Likewise, the study of structurally related and unrelated P-gp modulators indicated strong isoform-specific differences in the capacity of individual modulators to abrogate vinblastine resistance in the corresponding mdr transfectants. Vinblastine phosphoglycolate phosphatase Homo sapiens