Title : Cyclic AMP stimulates Ca2+ entry in rat hepatocytes by interacting with the plasma membrane carriers involved in receptor-mediated Ca2+ influx.

Pub. Date : 1994 Jul

PMID : 7818985






3 Functional Relationships(s)
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1 Exposing hepatocytes suspended in nominally Ca(2+)-free medium to glucagon for 3 min produced a 9% decrease in the size of the vasopressin-sensitive Ca2+ pool; in contrast, N6,2"-O-dibutyryladenosine 3":5"-cyclic monophosphate (Bt2cAMP) slightly augmented the size of this pool. Glucagon arginine vasopressin Rattus norvegicus
2 Glucagon and Bt2cAMP synergized the initial vasopressin-stimulated Ca2+ and Mn2+ influx rates, but only moderately increased the initial rate of Ca2+ entry after thapsigargin addition. Glucagon arginine vasopressin Rattus norvegicus
3 The glucagon- and Bt2cAMP-stimulated Ca2+ influx was inhibited by the same antagonists of the plasma membrane Ca2+ carriers that mediate Ca2+ entry during stimulation by vasopressin. Glucagon arginine vasopressin Rattus norvegicus