Title : Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo.

Pub. Date : 1995 Jun 15

PMID : 7780976






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) has been shown to repair nitrosourea-induced DNA damage. Nitrosourea Compounds O-6-methylguanine-DNA methyltransferase Mus musculus
2 The DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) has been shown to repair nitrosourea-induced DNA damage. Nitrosourea Compounds O-6-methylguanine-DNA methyltransferase Mus musculus
3 We therefore investigated the effect of expressing MGMT in hematopoietic cells (via retrovirus-mediated gene transfer) on nitrosourea-induced toxicity. Nitrosourea Compounds O-6-methylguanine-DNA methyltransferase Mus musculus
4 These data suggest that MGMT expression in hematopoietic progenitor and precursor cells protects against nitrosourea-induced toxicity and that gene transfer may prove useful in attempts to reduce nitrosourea-induced myelosuppression in the clinical setting. Nitrosourea Compounds O-6-methylguanine-DNA methyltransferase Mus musculus
5 These data suggest that MGMT expression in hematopoietic progenitor and precursor cells protects against nitrosourea-induced toxicity and that gene transfer may prove useful in attempts to reduce nitrosourea-induced myelosuppression in the clinical setting. Nitrosourea Compounds O-6-methylguanine-DNA methyltransferase Mus musculus