Title : Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines.

Pub. Date : 1995 Mar 1

PMID : 7780739






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Activation of the p42mapk isoform requires its phosphorylation at two residues, Thr 183 and Tyr 185, and this phosphorylation is catalysed by MAP kinase kinase (MAPKK). Tyrosine mitogen activated protein kinase 1 Rattus norvegicus
2 Recently, the CL100 phosphatase has been shown to inactivate p42mapk in vitro by dephosphorylating Thr 183 and Tyr 185 at similar rates. Tyrosine mitogen activated protein kinase 1 Rattus norvegicus
3 Phosphorylation of Thr 183 also inhibited the dephosphorylation of Tyr 185 in vitro by the major vanadate-sensitive Tyr 185-specific phosphatase, explaining why dephosphorylation of Thr 183 is rate-limiting for p42mapk inactivation in PC12 cells after stimulation with EGF. Tyrosine mitogen activated protein kinase 1 Rattus norvegicus
4 Phosphorylation of Thr 183 also inhibited the dephosphorylation of Tyr 185 in vitro by the major vanadate-sensitive Tyr 185-specific phosphatase, explaining why dephosphorylation of Thr 183 is rate-limiting for p42mapk inactivation in PC12 cells after stimulation with EGF. Tyrosine mitogen activated protein kinase 1 Rattus norvegicus