Title : Differential stabilization of eukaryotic DNA topoisomerase I cleavable complexes by camptothecin derivatives.

Pub. Date : 1995 May 30

PMID : 7766631






1 Functional Relationships(s)
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1 The stability of 10-hydroxycamptothecin-induced cleavable complexes was intermediate to those of CPT and SN-38, indicating that both the 10-hydroxy and the 7-ethyl group of SN-38 probably interact with the drug binding site of top1-cleavable complexes. 10-hydroxycamptothecin choline phosphotransferase 1 Homo sapiens