Pub. Date : 1995 Feb
PMID : 7736562
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pretreatment of TSMCs with phorbol 12-myristate 13-acetate (PMA, 1 microM) for 30 min blocked the ET-1-induced IP3 formation and Ca2+ mobilization. | Tetradecanoylphorbol Acetate | endothelin 1 | Canis lupus familiaris |
| 2 | Pretreatment of TSMCs with phorbol 12-myristate 13-acetate (PMA, 1 microM) for 30 min blocked the ET-1-induced IP3 formation and Ca2+ mobilization. | Tetradecanoylphorbol Acetate | endothelin 1 | Canis lupus familiaris |
| 3 | Following preincubation, ET-1-induced Ca2+ mobilization recovered with time and reached the same extent of control cells within 48 h. The concentrations of PMA that gave half-maximal inhibition (-logEC50) of ET-1-induced IP3 formation and increase in [Ca2+]i were 8.6 and 8.4 M, respectively. | Tetradecanoylphorbol Acetate | endothelin 1 | Canis lupus familiaris |
| 4 | Following preincubation, ET-1-induced Ca2+ mobilization recovered with time and reached the same extent of control cells within 48 h. The concentrations of PMA that gave half-maximal inhibition (-logEC50) of ET-1-induced IP3 formation and increase in [Ca2+]i were 8.6 and 8.4 M, respectively. | Tetradecanoylphorbol Acetate | endothelin 1 | Canis lupus familiaris |
| 5 | Prior treatment of TSMCs with staurosporine (1 microM), a PKC inhibitor, inhibited the ability of PMA to attenuate ET-1-induced responses, suggesting that the inhibitory effect of PMA is mediated through the activation of PKC. | Tetradecanoylphorbol Acetate | endothelin 1 | Canis lupus familiaris |
| 6 | In parallel with the effect of PMA on the ET-1-induced IP3 formation and Ca2+ mobilization, a change of PKC activity was observed in TSMCs. | Tetradecanoylphorbol Acetate | endothelin 1 | Canis lupus familiaris |