Title : Kinetic characterization of the proteinase binding defect in a reactive site variant of the serpin, antithrombin. Role of the P1' residue in transition-state stabilization of antithrombin-proteinase complex formation.

Pub. Date : 1995 Apr 28

PMID : 7730349






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 To elucidate the role of the P1" residue of the serpin, antithrombin (AT), in proteinase inhibition, the source of the functional defect in a natural Ser-394-->Leu variant, AT-Denver, was investigated. Leucine serpin family C member 1 Homo sapiens
2 To elucidate the role of the P1" residue of the serpin, antithrombin (AT), in proteinase inhibition, the source of the functional defect in a natural Ser-394-->Leu variant, AT-Denver, was investigated. Leucine serpin family C member 1 Homo sapiens